RNA polymerase II ChIP-seq—a powerful and highly affordable method for studying fungal genomics and physiology
نویسندگان
چکیده
منابع مشابه
RNA polymerase is a powerful torsional motor
DNA supercoiling has been recognized as an important regulator of gene expression in vivo. As RNA polymerase (RNAP) tracks the helical groove of DNA, it generates (+) DNA supercoiling ahead and (−) DNA supercoiling behind, as described by the “twin supercoiled domain model” proposed by James Wang. Initial studies suggested that transcription generated DNA supercoiling when RNAP and DNA are topo...
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The cell cycle and transcription by RNA polymerase II (RNAP II) are closely related. They utilize shared components. RNAP II transcriptional activity is modulated during the cell cycle. Cell cycle dependent changes in the phosphorylation status of the carboxyl-terminal domain (CTD) of the largest subunit of RNAP II (RNAP II-LS) alter transcription. Several CTD kinases are members of the cyclin-...
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ژورنال
عنوان ژورنال: Biophysical Reviews
سال: 2019
ISSN: 1867-2450,1867-2469
DOI: 10.1007/s12551-018-00497-9